Defender Plus Dewormer Tablets for Dogs

DOSAGE AND ADMINISTRATION:

• For oral administration only
• The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.
• For routine control adult dogs should be treated every month. For routine treatment a single dose is recommended.
• In the event of heavy roundworm infestation a repeat dose should be given after 14 days.

The recommended dose rates are:

1 tablet per 10 kg body weight or as directed by the Veterinarian.

PREGNANCY AND LACTATION:

• Consult a Veterinary before treating pregnant bitches for roundworms.
• The product may be used during lactation.
• Do not exceed recommended dose when treating   pregnant bitches.

CONTRA-INDICATIONS, WARNINGS:

Do not use simultaneously with piperazine compounds.

USER SAFETY:

In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog`s food, should wash their hands afterwards.

ENVIRONMENTAL SAFETY:

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

PRECAUTIONS:

Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Infected dogs treated for the first time with Defender Plus Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. If these procedures are not possible, the eggs can be destroyed by soaking the feces in a sodium hypochlorite (bleach) solution of 3.75% or greater. All areas where the animal was maintained or in contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.

Defender Plus should be used alone and never combined with other de-worming medicine.

ADVERSE DRUG REACTIONS:

None reported. Vomiting was reported in some cases.

Technical Description:

Defender Plus Tablets contain three active ingredients having different modes of action and spectra of activity.

Praziquantel is active against cestodes (tapeworms). Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool.

Pyrantel pamoate is active against hookworms and ascarids. Pyrantel Pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the parasite.

Febantel is active against nematode parasites including whipworms. Febantel is rapidly absorbed and metabolized in the animal.

Available information suggests that the parasite’s energy metabolism is blocked, leading to energy exchange breakdown and inhibited glucose uptake.